Submit a comment

Effect of Captopril on Uterine Blood Flow and Prostaglandin E Synthesis in the Pregnant Rabbit
Thomas F. Ferris, Edward K. Weir
Thomas F. Ferris, Edward K. Weir
Published April 1, 1983
Citation Information: J Clin Invest. 1983;71(4):809-815. https://doi.org/10.1172/JCI110834.
View: Text | PDF
Research Article

Effect of Captopril on Uterine Blood Flow and Prostaglandin E Synthesis in the Pregnant Rabbit

Abstract

Captopril, 5 mg/kg, administered to pregnant rabbits caused a reduction in mean arterial pressure (MAP) from 106±2 to 87±2 mmHg (P<0.01) without change in cardiac output or renal blood flow. Uterine blood flow fell from 31.9±2.5 to 21.3±3.4 ml/min (P<0.01) as uterine vein prostaglandin E series level (PGE) decreased from 127±23 ng/ml to 26±8 ng/ml (P<0.01). Saralasin also caused a reduction in MAP from 110±5 to 92±4.3 (P<0.01), a reduction in uterine blood flow from 28.8±1.6 to 21.8±1.7 ml/min (P<0.01) as uterine vein PGE decreased from 121.3±14.4 to 63.5±14.2 ng/ml (P<0.01). Plasma renin activity (PRA) was higher in the uterine vein, 11±3 ng/ml per h, than peripheral vein, 6±1.6 ng/ml per h, (P<0.05), before Captopril and rose in the uterine vein to 90±19 ng/ml per h (P<0.01) as peripheral vein PRA rose to 62±15 ng/ml per h (P<0.05) after Captopril. After saralasin uterine vein PRA rose from 4.6±1.5 to 14.8±6.3 ng/ml per h (P<0.05) and peripheral vein PRA rose from 3.7±1 to 6.5±2.1 (P<0.05).

Authors

Thomas F. Ferris, Edward K. Weir

×

Guidelines

The Editorial Board will only consider comments that are deemed relevant and of interest to readers. The Journal will not post data that have not been subjected to peer review; or a comment that is essentially a reiteration of another comment.

  • Comments appear on the Journal’s website and are linked from the original article’s web page.
  • Authors are notified by email if their comments are posted.
  • The Journal reserves the right to edit comments for length and clarity.
  • No appeals will be considered.
  • Comments are not indexed in PubMed.

Specific requirements

  • Maximum length, 400 words
  • Entered as plain text or HTML
  • Author’s name and email address, to be posted with the comment
  • Declaration of all potential conflicts of interest (even if these are not ultimately posted); see the Journal’s conflict-of-interest policy
  • Comments may not include figures
This field is required
This field is required
This field is required
This field is required
This field is required
This field is required