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Role of Ia-Like Products of the Main Histocompatibility Complex in Conditioning Skin Allograft Survival in Man
J. Dausset, … , T. Meo, F. T. Rapaport
J. Dausset, … , T. Meo, F. T. Rapaport
Published May 1, 1979
Citation Information: J Clin Invest. 1979;63(5):893-901. https://doi.org/10.1172/JCI109389.
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Research Article

Role of Ia-Like Products of the Main Histocompatibility Complex in Conditioning Skin Allograft Survival in Man

Abstract

This report correlates the survival time of 93 intrafamilial skin allografts performed under conditions of main histocompatibility complex (HLA) haploidentity with donor-recipient compatibility for products of the HLA-A, -B, -C, and -DR, as well as C3 proactivator, Glyoxalase I, and P loci located on the human 6th chromosome. Incompatibilities for HLA-A and -B (and to a lesser extent for HLA-C) and(or) for HLA-DR products exerted a strong influence upon the fate of skin allografts. When HLA-A and -B were considered alone, the most compatible group of grafts had a mean survival time of 15.8 d, as compared with 11.3 d for the most incompatible transplants. HLA-DR compatibility alone was associated with a mean survival time of 15.3 d, whereas HLA-DR-incompatible grafts had a mean survival time of 11.5 d. Incompatibilities for C3 proactivator, Glyoxalase I, and P did not have a significant effect upon graft survival.

Authors

J. Dausset, L. Contu, L. Legrand, A. Marcelli-Barge, T. Meo, F. T. Rapaport

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