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Research Article Free access | 10.1172/JCI109389

Role of Ia-Like Products of the Main Histocompatibility Complex in Conditioning Skin Allograft Survival in Man

J. Dausset, L. Contu, L. Legrand, A. Marcelli-Barge, T. Meo, and F. T. Rapaport

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Dausset, J. in: PubMed | Google Scholar

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Contu, L. in: PubMed | Google Scholar

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Legrand, L. in: PubMed | Google Scholar

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Marcelli-Barge, A. in: PubMed | Google Scholar

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Meo, T. in: PubMed | Google Scholar

Research Unit on Human Transplantation and Immunogenetics, Institut National de la Santé et de la Recherche Medicale, Unit 93, Hôpital Saint-Louis, Paris 75010, France

Department of Surgery, State University of New York at Stony Brook, Stony Brook, New York 11794

Find articles by Rapaport, F. in: PubMed | Google Scholar

Published May 1, 1979 - More info

Published in Volume 63, Issue 5 on May 1, 1979
J Clin Invest. 1979;63(5):893–901. https://doi.org/10.1172/JCI109389.
© 1979 The American Society for Clinical Investigation
Published May 1, 1979 - Version history
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Abstract

This report correlates the survival time of 93 intrafamilial skin allografts performed under conditions of main histocompatibility complex (HLA) haploidentity with donor-recipient compatibility for products of the HLA-A, -B, -C, and -DR, as well as C3 proactivator, Glyoxalase I, and P loci located on the human 6th chromosome. Incompatibilities for HLA-A and -B (and to a lesser extent for HLA-C) and(or) for HLA-DR products exerted a strong influence upon the fate of skin allografts. When HLA-A and -B were considered alone, the most compatible group of grafts had a mean survival time of 15.8 d, as compared with 11.3 d for the most incompatible transplants. HLA-DR compatibility alone was associated with a mean survival time of 15.3 d, whereas HLA-DR-incompatible grafts had a mean survival time of 11.5 d. Incompatibilities for C3 proactivator, Glyoxalase I, and P did not have a significant effect upon graft survival.

There was no evidence of an association between donor-recipient incompatibility at HLA-A, -B, or -C or at HLA-DR; such incompatibilities occurred independently of each other, in spite of the state of linkage disequilibrium known to exist between HLA-B and -DR. Incompatibilities for HLA-A, -B, and for HLA-DR exerted a potent additive effect upon graft survival. Skin grafts bearing one, two, or three incompatibilities had a mean survival time of 16.2, 13.7, and 10.7 d, respectively (P <0.0005).

The results point to the important role played by the Ia-like products of the HLA complex (HLA-DR) in conditioning skin allograft survival in man. This consideration may be of direct relevance to the potential clinical usefulness of in vitro serological techniques for the detection of donor-recipient compatibility for HLA-DR.

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