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“Activation” of vitamin D by the liver
G. Ponchon, … , A. L. Kennan, H. F. DeLuca
G. Ponchon, … , A. L. Kennan, H. F. DeLuca
Published November 1, 1969
Citation Information: J Clin Invest. 1969;48(11):2032-2037. https://doi.org/10.1172/JCI106168.
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Research Article

“Activation” of vitamin D by the liver

Abstract

Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-3H vitamin D3 into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D3 (cholecalciferol) into 25-hydroxycholecalciferol.

Authors

G. Ponchon, A. L. Kennan, H. F. DeLuca

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