Advertisement
Research Article Free access | 10.1172/JCI106168
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53706
Find articles by Ponchon, G. in: JCI | PubMed | Google Scholar
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53706
Find articles by Kennan, A. in: JCI | PubMed | Google Scholar
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53706
Find articles by DeLuca, H. in: JCI | PubMed | Google Scholar
Published November 1, 1969 - More info
Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-3H vitamin D3 into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D3 (cholecalciferol) into 25-hydroxycholecalciferol.
The osteodystrophy and the higher requirements for vitamin D observed in hepatic insufficiencies may be due to an inability of the liver to transform vitamin D into its metabolically active form.