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Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia
Robert S. Hillman
Robert S. Hillman
Published March 1, 1969
Citation Information: J Clin Invest. 1969;48(3):443-453. https://doi.org/10.1172/JCI106001.
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Research Article

Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia

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Abstract

Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity. This study permitted a comparison of marrow production measurements over a wide range of marrow production levels. As long as the serum iron remained above 50 μg/100 ml, measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production. In contrast, the absolute reticulocyte count demonstrated a poor correlation with the other measurements. This was shown to be the result of a prolongation of the time required for circulating reticulocytes to lose their reticulum, which correlated with the severity of the anemia. For the clinical application of the reticulocyte count as a measurement of marrow production, an adjustment must be made for this alteration in the circulating reticulocyte maturation time.

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Robert S. Hillman

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