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Citation Information: J Clin Invest. 1967;46(7):1178-1188. https://doi.org/10.1172/JCI105611.
Abstract
The functional characteristics of the ascending limb of Henle's loop were examined during hypotonic saline infusion by measuring solutefree water clearance (CH2O) at varying rates of solute delivery. The influence of expansion of extracellular volume was studied by comparing CH2O during hypotonic saline diuresis in normal dogs with dogs whose extracellular volume had been expanded acutely by saline infusions or chronically by the administration of deoxycorticosterone acetate and salt.
Authors
Garabed Eknoyan, Wadi N. Suki, Floyd C. Rector Jr., Donald W. Seldin
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