Functional Characteristics of the Diluting Segment of the Dog Nephron and the Effect of Extracellular Volume Expansion on its Reabsorptive Capacity

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Abstract

The functional characteristics of the ascending limb of Henle's loop were examined during hypotonic saline infusion by measuring solutefree water clearance (CH2O) at varying rates of solute delivery. The influence of expansion of extracellular volume was studied by comparing CH2O during hypotonic saline diuresis in normal dogs with dogs whose extracellular volume had been expanded acutely by saline infusions or chronically by the administration of deoxycorticosterone acetate and salt.

Authors

Garabed Eknoyan, Wadi N. Suki, Floyd C. Rector Jr., Donald W. Seldin