Key roles for lipid mediators in the adaptive immune response
Parker F. Duffney,1,2 Megan L. Falsetta,1,2 Ashley R. Rackow,1,2 Thomas H. Thatcher,2,3 Richard P. Phipps,1,2,3 and Patricia J. Sime1,2,3
1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
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1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
Find articles by Falsetta, M. in: JCI | PubMed | Google Scholar
1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
Find articles by Rackow, A. in: JCI | PubMed | Google Scholar
1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
Find articles by Thatcher, T. in: JCI | PubMed | Google Scholar
1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
Find articles by Phipps, R. in: JCI | PubMed | Google Scholar
1Department of Environmental Medicine,
2Lung Biology and Disease Program, and
3Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Address correspondence to: Patricia J. Sime, University of Rochester, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 601 Elmwood Avenue, Box 692, Rochester, New York 14642, USA. Phone: 585.275.6526; Email: Patricia_Sime@urmc.rochester.edu.
Find articles by Sime, P. in: JCI | PubMed | Google Scholar
First published July 2, 2018 - More info
J Clin Invest. 2018;128(7):2724–2731. https://doi.org/10.1172/JCI97951.
Copyright © 2018, American Society for Clinical Investigation
Chronic inflammation is an underlying feature of many diseases, including chronic obstructive pulmonary disease, rheumatoid arthritis, asthma, and multiple sclerosis. There is an increasing appreciation of the dysregulation of adaptive immunity in chronic inflammatory and allergic diseases. The discovery of specialized pro-resolving lipid mediators (SPMs) that actively promote the resolution of inflammation has opened new avenues for the treatment of chronic inflammatory diseases. Much work has been done focusing on the impact of SPMs on innate immune cells. However, much less is known about the influence of SPMs on the development of antigen-specific adaptive immune responses. This Review highlights the important breakthroughs concerning the effects of SPMs on the key cell types involved in the development of adaptive immunity, namely dendritic cells, T cells, and B cells.
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