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Usage Information

Leukotriene receptors as potential therapeutic targets
Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu
Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu
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Review Series

Leukotriene receptors as potential therapeutic targets

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Abstract

Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as mediators of allergic and inflammatory reactions and considered to be important drug targets. Although an inhibitor of leukotriene biosynthesis and antagonists of the cysteinyl leukotriene receptor are clinically used for bronchial asthma and allergic rhinitis, these medications were developed before the molecular identification of leukotriene receptors. Numerous studies using cloned leukotriene receptors and genetically engineered mice have unveiled new pathophysiological roles for leukotrienes. This Review covers the recent findings on leukotriene receptors to revisit them as new drug targets.

Authors

Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
Text version 2,188 451
PDF 245 48
Figure 326 1
Table 112 0
Citation downloads 119 0
Totals 2,990 500
Total Views 3,490
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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