Maturing of the nuclear receptor family
Mitchell A. Lazar
Institute for Diabetes, Obesity, and Metabolism and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Address correspondence to: Mitchell A. Lazar, University of Pennsylvania Perelman School of Medicine, Institute for Diabetes, Obesity, and Metabolism, 12-102 Smilow Center for Translational Research Center, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA. Phone: 215.898.0198; E-mail: lazar@mail.med.upenn.edu.
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First published April 3, 2017 - More info
J Clin Invest. 2017;127(4):1123–1125. doi:10.1172/JCI92949.
Copyright © 2017, American Society for Clinical Investigation
Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the
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