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Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis
James L.M. Ferrara, … , Pavan Reddy, Jonathan S. Serody
James L.M. Ferrara, … , Pavan Reddy, Jonathan S. Serody
Published June 5, 2017
Citation Information: J Clin Invest. 2017;127(7):2441-2451. https://doi.org/10.1172/JCI90592.
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Review Series

Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis

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Abstract

Lower gastrointestinal (GI) tract graft-versus-host disease (GVHD) is the predominant cause of morbidity and mortality from GVHD after allogeneic stem cell transplantation. Recent data indicate that lower GI tract GVHD is a complicated process mediated by donor/host antigenic disparities. This process is exacerbated by significant changes to the microbiome, and innate and adaptive immune responses that are critical to the induction of disease, persistence of inflammation, and a lack of response to therapy. Here, we discuss new insights into the biology of lower GI tract GVHD and focus on intrinsic pathways and regulatory mechanisms crucial to normal intestinal function. We then describe multiple instances in which these homeostatic mechanisms are altered by donor T cells or conditioning therapy, resulting in exacerbation of GVHD. We also discuss data suggesting that some of these mechanisms produce biomarkers that could be informative as to the severity of GVHD and its response to therapy. Finally, novel therapies that might restore homeostasis in the GI tract during GVHD are highlighted.

Authors

James L.M. Ferrara, Christopher M. Smith, Julia Sheets, Pavan Reddy, Jonathan S. Serody

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Figure 1

Early gastrointestinal GVHD pathophysiology.

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Early gastrointestinal GVHD pathophysiology.
At steady state, intestinal...
At steady state, intestinal stem cells (ISCs) reside next to Paneth cells at the base of intestinal crypts. Homeostasis is maintained, in part, by large numbers of commensal bacteria that stimulate IL-22 production by ILC3s. Commensal bacteria also produce metabolites such as butyrate, which promote the health of Tregs, as well as enterocytes and ILC2s, which maintain antiinflammatory myeloid-derived suppressor cells (MDSCs) and enhance GI barrier function. During allo-HCT, ILC2s are eliminated by hematopoietic cell transplant (HCT) conditioning, resulting in diminished antiinflammatory properties in the GI tract. However, ILC3s, which secrete IL-22 that protects ISCs and induces regenerating family member 3α (REG3) in Paneth cells, resist host conditioning. REG3 is concentrated in the mucus that shields the sterile surfaces of enterocytes from potential pathogens present in the intestinal microbiome. After allo-HCT, donor conventional T cells (Tcons) recognize histocompatibility antigens on both hematopoietic (HP) and non-HP APCs. Activated Tcons proliferate and trigger release of alarmins, such as IL-33 and its soluble receptor ST2, from non-HP APCs, such as stromal cells and endothelium; these activated Tcons also express the integrin receptor α4β7, which directs their migration back to intestinal tissue after entering the villus capillaries.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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