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Citations to this article

Atrial-specific pathways for control of intracellular signaling and myocyte function
Thomas J. Hund, Peter J. Mohler
Thomas J. Hund, Peter J. Mohler
Published September 19, 2016
Citation Information: J Clin Invest. 2016;126(10):3731-3734. https://doi.org/10.1172/JCI90348.
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Commentary

Atrial-specific pathways for control of intracellular signaling and myocyte function

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Abstract

Atrial fibrillation (AF) is a cardiac arrhythmia that arises from electrical and contractile dysfunction in the atria. Atrial function is regulated by a variety of intracellular signaling networks that facilitate rapid communication and coordinate responses of atrial myocytes. In this issue of the JCI, Brandenburg and colleagues describe the identification and characterization of “super-hub” signaling nodes located on atrial axial tubules that regulate atrial contraction. Together, the results of this study provide important insight into the regulation of atrial contraction and describe potential therapeutic targets to be explored in future studies.

Authors

Thomas J. Hund, Peter J. Mohler

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