Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Atrial-specific pathways for control of intracellular signaling and myocyte function
Thomas J. Hund, Peter J. Mohler
Thomas J. Hund, Peter J. Mohler
Published September 19, 2016
Citation Information: J Clin Invest. 2016;126(10):3731-3734. https://doi.org/10.1172/JCI90348.
View: Text | PDF
Commentary

Atrial-specific pathways for control of intracellular signaling and myocyte function

  • Text
  • PDF
Abstract

Atrial fibrillation (AF) is a cardiac arrhythmia that arises from electrical and contractile dysfunction in the atria. Atrial function is regulated by a variety of intracellular signaling networks that facilitate rapid communication and coordinate responses of atrial myocytes. In this issue of the JCI, Brandenburg and colleagues describe the identification and characterization of “super-hub” signaling nodes located on atrial axial tubules that regulate atrial contraction. Together, the results of this study provide important insight into the regulation of atrial contraction and describe potential therapeutic targets to be explored in future studies.

Authors

Thomas J. Hund, Peter J. Mohler

×

Figure 1

Cardiac atrial signaling “hubs” regulate local calcium signaling.

Options: View larger image (or click on image) Download as PowerPoint
Cardiac atrial signaling “hubs” regulate local calcium signaling.
(A) Sc...
(A) Schematic of the atrial myocyte TT and AT networks and the SR. In this issue, Brandenburg et al. have described an atrial “super hub” (inset), which harbors a unique signaling platform with CRUs and regulatory proteins. RyR2 clusters are differentially regulated at TT and AT domains, potentially due to a distinct constituency of regulatory macromolecular complexes. (B) Schematic showing the distribution of hyperphosphorylated (red) and unphosphorylated (blue) CRUs in association with ATs and TTs at baseline, following β-AR stimulation, and in atrial hypertrophy.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts