As Editor of the Journal of Clinical Investigation, I am pleased to announce the January 2016 launch of JCI Insight, which will publish well-executed, high-quality research across biomedicine that presents a focused yet insightful line of investigation. The new journal, published under an open-access model, represents an expansion of the American Society for Clinical Investigation’s longstanding commitment to disseminating preclinical, translational, and early-phase clinical research that has the potential to advance the practice of medicine. JCI Insight will be the second Society publication since the JCI was founded in 1924.