Calcium release channel RyR2 regulates insulin release and glucose homeostasis

¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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¹Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

²Department of Medicine, Imperial College, London, United Kingdom.

³Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.

⁴Department of Translational Medical Sciences, “Federico II” University, Naples, Italy.

⁵Department of Electrophysiology, the Leiden University Medical Center (LUMC), Leiden, Netherlands.

⁶Department of Medical, Surgical, Neurological, Metabolic, and Geriatric Sciences, Second University of Naples, Naples, Italy.

⁷Department of Cardiovascular Disorders, Catholic University of the Sacred Heart, “John Paul II” Foundation for Research and Treatment, Campobasso, Italy.

⁸Department of Cardiology and Arrhythmology, Clinical Institute “Città Studi” Hospital, Milan, Italy.

⁹Division of Cardiology, G. Tatarella Hospital, Cerignola (Foggia), Italy.

¹⁰Cardiology Department, Clinical Research Unit IV, Division of Cardiology, Niguarda Ca’Granda Hospital, Milan, Italy.

¹¹Cardiovascular Department, ASL3 Ospedale San Francesco, Nuoro, Italy.

¹²Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy.

¹³Department of Medicine, Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

¹⁴U1046 INSERM, UMR 9214, CNRS, CHRU Montpellier, Montpellier, France.

¹⁵Department of Medicine, Columbia University, New York, New York, USA.

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