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Usage Information

Hypoxia-inducible factors: a central link between inflammation and cancer
Daniel Triner, Yatrik M. Shah
Daniel Triner, Yatrik M. Shah
Published August 15, 2016
Citation Information: J Clin Invest. 2016;126(10):3689-3698. https://doi.org/10.1172/JCI84430.
View: Text | PDF
Review Series

Hypoxia-inducible factors: a central link between inflammation and cancer

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Abstract

The tumor immune response is in a dynamic balance between antitumor mechanisms, which serve to decrease cancer growth, and the protumor inflammatory response, which increases immune tolerance, cell survival, and proliferation. Hypoxia and expression of HIF-1α and HIF-2α are characteristic features of all solid tumors. HIF signaling serves as a major adaptive mechanism in tumor growth in a hypoxic microenvironment. HIFs represent a critical signaling node in the switch to protumorigenic inflammatory responses through recruitment of protumor immune cells and altered immune cell effector functions to suppress antitumor immune responses and promote tumor growth through direct growth-promoting cytokine production, angiogenesis, and ROS production. Modulating HIF function will be an important mechanism to dampen the tumor-promoting inflammatory response and inhibit cancer growth.

Authors

Daniel Triner, Yatrik M. Shah

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Usage data is cumulative from March 2022 through March 2023.

Usage JCI PMC
Text version 1,386 288
PDF 166 75
Figure 352 0
Table 94 0
Citation downloads 50 0
Totals 2,048 363
Total Views 2,411
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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