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Usage Information

Hypoxia-inducible factors: a central link between inflammation and cancer
Daniel Triner, Yatrik M. Shah
Daniel Triner, Yatrik M. Shah
Published August 15, 2016
Citation Information: J Clin Invest. 2016;126(10):3689-3698. https://doi.org/10.1172/JCI84430.
View: Text | PDF
Review Series

Hypoxia-inducible factors: a central link between inflammation and cancer

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Abstract

The tumor immune response is in a dynamic balance between antitumor mechanisms, which serve to decrease cancer growth, and the protumor inflammatory response, which increases immune tolerance, cell survival, and proliferation. Hypoxia and expression of HIF-1α and HIF-2α are characteristic features of all solid tumors. HIF signaling serves as a major adaptive mechanism in tumor growth in a hypoxic microenvironment. HIFs represent a critical signaling node in the switch to protumorigenic inflammatory responses through recruitment of protumor immune cells and altered immune cell effector functions to suppress antitumor immune responses and promote tumor growth through direct growth-promoting cytokine production, angiogenesis, and ROS production. Modulating HIF function will be an important mechanism to dampen the tumor-promoting inflammatory response and inhibit cancer growth.

Authors

Daniel Triner, Yatrik M. Shah

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,240 229
PDF 138 56
Figure 263 0
Table 83 0
Citation downloads 123 0
Totals 1,847 285
Total Views 2,132
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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