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PTP1B: a new therapeutic target for Rett syndrome
Lutz Tautz
Lutz Tautz
Published July 27, 2015
Citation Information: J Clin Invest. 2015;125(8):2931-2934. https://doi.org/10.1172/JCI83192.
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Commentary

PTP1B: a new therapeutic target for Rett syndrome

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Abstract

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that is characterized by successive loss of acquired cognitive, social, and motor skills and development of autistic behavior. RTT affects approximately 1 in 10,000 live female births and is the second most common cause of severe mental retardation in females, after Down syndrome. Currently, there is no cure or effective therapy for RTT. Approved treatment regimens are presently limited to supportive management of specific physical and mental disabilities. In this issue, Krishnan and colleagues reveal that the protein tyrosine phosphatase PTP1B is upregulated in patients with RTT and in murine models and provide strong evidence that targeting PTP1B has potential as a viable therapeutic strategy for the treatment of RTT.

Authors

Lutz Tautz

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