Published May 1, 2015 - More info
Posttranslationally modified proteins serve as autoimmunogenic targets in a wide spectrum of autoimmune diseases. Here, we identified a posttranslationally modified paraprotein target (paratargs) in monoclonal gammopathies of undetermined significance (MGUS), multiple myelomas (MM), and Waldenstrom’s macroglobulinemias (WM) using protein macroarrays that were sumoylated and screened for reactivity with paraproteins from MGUS, MM, and WM patients. We found that paraproteins from a proportion of European, African-American, and Japanese patients specifically reacted with the sumoylated heat-shock protein 90 β isoform-α (HSP90-SUMO1, where SUMO indicates
Klaus-Dieter Preuss, Michael Pfreundschuh, Natalie Fadle, Evi Regitz, Boris Kubuschok
José Carreras Center for Immuno- and Gene Therapy, Internal Medicine I, Saarland University Medical School, Homburg (Saar), Germany.
Original citation: J Clin Invest. 2015;125(1):316–323. doi:10.1172/JCI76802.
Citation for this corrigendum: J Clin Invest. 2015;125(5):2179. doi:10.1172/JCI82091.
Martin Weigert was inadvertently omitted from the author list. The correct author and affiliation lists appear above.
The authors regret the error.