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Systems biology of diuretic resistance
Mark A. Knepper
Mark A. Knepper
Published April 20, 2015
Citation Information: J Clin Invest. 2015;125(5):1793-1795. https://doi.org/10.1172/JCI81505.
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Commentary

Systems biology of diuretic resistance

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Abstract

Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall process involves interactions among six different cell types in the kidney.

Authors

Mark A. Knepper

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