Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Lung inflammatory injury and tissue repair (Jul 2023)
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Systems biology of diuretic resistance
Mark A. Knepper
Mark A. Knepper
Published April 20, 2015
Citation Information: J Clin Invest. 2015;125(5):1793-1795. https://doi.org/10.1172/JCI81505.
View: Text | PDF
Commentary

Systems biology of diuretic resistance

  • Text
  • PDF
Abstract

Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall process involves interactions among six different cell types in the kidney.

Authors

Mark A. Knepper

×

Figure 1

Compensation for Na-Cl transport loss in the DCT involves changes in multiple renal cell types.

Options: View larger image (or click on image) Download as PowerPoint
Compensation for Na-Cl transport loss in the DCT involves changes in mul...
Using a systems biology approach, Grimm and colleagues (1) concluded that multiple renal cell types are involved in the compensatory response to thiazides. The identified cell types include DCT cells (green), α-ICs (gray), CNT cells, CCD PCs (CNT cells and CCD PCs, coral), PT cells (yellow), and β-ICs (blue). Together, adaptive responses in these cells coordinate an integrated compensatory network in the kidney. See ref. 1 for details. ECF, extracellular fluid.

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts