In vivo platforms for analysis of HIV persistence and eradication
J. Victor Garcia
J. Victor Garcia
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Review Series

In vivo platforms for analysis of HIV persistence and eradication

Abstract

HIV persistence in patients undergoing antiretroviral therapy is a major impediment to the cure of HIV/AIDS. The molecular and cellular mechanisms underlying HIV persistence in vivo have not been fully elucidated. This lack of basic knowledge has hindered progress in this area. The in vivo analysis of HIV persistence and the implementation of curative strategies would benefit from animal models that accurately recapitulate key aspects of the human condition. This Review summarizes the contribution that humanized mouse models of HIV infection have made to the field of HIV cure research. Even though these models have been shown to be highly informative in many specific areas, their great potential to serve as excellent platforms for discovery in HIV pathogenesis and treatment has yet to be fully developed.

Authors

J. Victor Garcia

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Figure 2

Analysis of “kick and kill” strategies in humanized mice.

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Analysis of “kick and kill” strategies in humanized mice. Diagram illust...
Diagram illustrating the different steps in the process of evaluating induction and/or HIV-infected cell–killing strategies in humanized mice. Humanized mice are first exposed to HIV via parenteral or mucosal routes. Once systemic viremia has been established, antiretroviral drugs are administered either orally or via i.p. injection. Once HIV is suppressed below the limit of detection, mice can be treated with induction and/or killing approaches. Several candidates for induction and HIV-infected cell killing are shown. bNAbs, broadly neutralizing Abs; ImmTox, immunotoxins.