Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Corrigendum Free access | 10.1172/JCI76901

Disrupted cortical function underlies behavior dysfunction due to social isolation

Tomoyuki Miyazaki, Kenkichi Takase, Waki Nakajima, Hirobumi Tada, Daisuke Ohya, Akane Sano, Takahisa Goto, Hajime Hirase, Roberto Malinow, and Takuya Takahashi

Find articles by Miyazaki, T. in: PubMed | Google Scholar

Find articles by Takase, K. in: PubMed | Google Scholar

Find articles by Nakajima, W. in: PubMed | Google Scholar

Find articles by Tada, H. in: PubMed | Google Scholar

Find articles by Ohya, D. in: PubMed | Google Scholar

Find articles by Sano, A. in: PubMed | Google Scholar

Find articles by Goto, T. in: PubMed | Google Scholar

Find articles by Hirase, H. in: PubMed | Google Scholar

Find articles by Malinow, R. in: PubMed | Google Scholar

Find articles by Takahashi, T. in: PubMed | Google Scholar

Published June 2, 2014 - More info

Published in Volume 124, Issue 6 on June 2, 2014
J Clin Invest. 2014;124(6):2807–2807. https://doi.org/10.1172/JCI76901.
© 2014 The American Society for Clinical Investigation
Published June 2, 2014 - Version history
View PDF

Related article:

Disrupted cortical function underlies behavior dysfunction due to social isolation
Tomoyuki Miyazaki, … , Roberto Malinow, Takuya Takahashi
Tomoyuki Miyazaki, … , Roberto Malinow, Takuya Takahashi
Research Article Neuroscience

Disrupted cortical function underlies behavior dysfunction due to social isolation

  • Text
  • PDF
Abstract

Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. Here, we show that neonatal social isolation disrupts molecular, cellular, and circuit developmental processes, leading to behavioral dysfunction. Neonatal isolation prevented long-term potentiation and experience-dependent synaptic trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors normally occurring during circuit formation in the rodent barrel cortex. This inhibition of AMPA receptor trafficking was mediated by an increase of the stress glucocorticoid hormone and was associated with reduced calcium/calmodulin-dependent protein kinase type II (CaMKII) signaling, resulting in attenuated whisker sensitivity at the cortex. These effects led to defects in whisker-dependent behavior in juvenile animals. These results indicate that neonatal social isolation alters neuronal plasticity mechanisms and perturbs the initial establishment of a normal cortical circuit, which potentially explains the long-lasting behavioral effects of neonatal stress.

Authors

Tomoyuki Miyazaki, Kenkichi Takase, Waki Nakajima, Hirobumi Tada, Daisuke Ohya, Akane Sano, Takahisa Goto, Hajime Hirase, Roberto Malinow, Takuya Takahashi

×

Original citation: J. Clin. Invest. 2012;122(7):2690–2701. doi:10.1172/JCI63060.

Citation for this corrigendum: J. Clin. Invest. 2014;124(6):2807. doi:10.1172/JCI76901.

During the preparation of this manuscript, raw Western blotting data were inadvertently not included in the Supplemental material file, and a sentence referring to that data was not included at the end of the Figure 4 legend and also at the end of the Supplemental Figure 1 legend. The data have been added to the Supplemental material as Supplemental Figure 7, and the correct sentence is below.

See also Supplemental Figure 7.

The authors regret the error.

Version history
  • Version 1 (June 2, 2014): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts