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Usage Information

Gut chemosensing mechanisms
Arianna Psichas, … , Frank Reimann, Fiona M. Gribble
Arianna Psichas, … , Frank Reimann, Fiona M. Gribble
Published February 9, 2015
Citation Information: J Clin Invest. 2015;125(3):908-917. https://doi.org/10.1172/JCI76309.
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Review Series

Gut chemosensing mechanisms

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Abstract

The enteroendocrine system is the primary sensor of ingested nutrients and is responsible for secreting an array of gut hormones, which modulate multiple physiological responses including gastrointestinal motility and secretion, glucose homeostasis, and appetite. This Review provides an up-to-date synopsis of the molecular mechanisms underlying enteroendocrine nutrient sensing and highlights our current understanding of the neuro-hormonal regulation of gut hormone secretion, including the interaction between the enteroendocrine system and the enteric nervous system. It is hoped that a deeper understanding of how these systems collectively regulate postprandial physiology will further facilitate the development of novel therapeutic strategies.

Authors

Arianna Psichas, Frank Reimann, Fiona M. Gribble

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Usage data is cumulative from September 2024 through September 2025.

Usage JCI PMC
Text version 1,741 173
PDF 118 37
Figure 257 0
Citation downloads 91 0
Totals 2,207 210
Total Views 2,417
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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