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Corrigendum Free access | 10.1172/JCI74037

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

Andrea Casazza, Veronica Finisguerra, Lorena Capparuccia, Andrea Camperi, Jakub M. Swiercz, Sabrina Rizzolio, Charlotte Rolny, Claus Christensen, Andrea Bertotti, Ivana Sarotto, Mauro Risio, Livio Trusolino, Jurgen Weitz, Martin Schneider, Massimilano Mazzone, Paolo M. Comoglio, and Luca Tamagnone

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Published December 2, 2013 - More info

Published in Volume 123, Issue 12 on December 2, 2013
J Clin Invest. 2013;123(12):5411–5411. https://doi.org/10.1172/JCI74037.
© 2013 The American Society for Clinical Investigation
Published December 2, 2013 - Version history
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Related article:

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
Andrea Casazza, … , Paolo M. Comoglio, Luca Tamagnone
Andrea Casazza, … , Paolo M. Comoglio, Luca Tamagnone
Research Article

Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

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Abstract

Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Sema3E is also highly expressed in metastatic cancer cells, but its mechanistic role in tumor progression was not understood. Here we show that expression of Sema3E and its receptor Plexin D1 correlates with the metastatic progression of human tumors. Consistent with the clinical data, knocking down endogenous expression of either Sema3E or Plexin D1 in human metastatic carcinoma cells hampered their metastatic potential when injected into mice, while tumor growth was not markedly affected. Conversely, overexpression of exogenous Sema3E in cancer cells increased their invasiveness, transendothelial migration, and metastatic spreading, although it inhibited tumor vessel formation, resulting in reduced tumor growth in mice. The proinvasive and metastatic activity of Sema3E in tumor cells was dependent on transactivation of the Plexin D1–associated ErbB2/Neu oncogenic kinase. In sum, Sema3E–Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis.

Authors

Andrea Casazza, Veronica Finisguerra, Lorena Capparuccia, Andrea Camperi, Jakub M. Swiercz, Sabrina Rizzolio, Charlotte Rolny, Claus Christensen, Andrea Bertotti, Ivana Sarotto, Mauro Risio, Livio Trusolino, Jurgen Weitz, Martin Schneider, Massimilano Mazzone, Paolo M. Comoglio, Luca Tamagnone

×

Original citation: J Clin Invest. 2010;120(8):2684–2698. doi:10.1172/JCI42118.

Citation for this corrigendum: J Clin Invest. 2013;123(12):5411. doi:10.1172/JCI74037.

During the assembly of Figure 2G of this manuscript, the p61 band in the shRNA Sema3E lane of the anti-Sema3E blot was intentionally skewed to appear straightened. The original, unadjusted Sema3E blot is shown in the corrected figure panel below. The authors were also able to demonstrate comparable results, which were provided to the journal, for Sema3E knockdown in 4T1 cells in replicate experiments.

Figure 2

The authors regret the error.

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