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Usage Information

Radiation and immunotherapy: a synergistic combination
Anusha Kalbasi, Carl H. June, Naomi Haas, Neha Vapiwala
Anusha Kalbasi, Carl H. June, Naomi Haas, Neha Vapiwala
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Clinical Review

Radiation and immunotherapy: a synergistic combination

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Abstract

Immunotherapy can be an effective treatment for metastatic cancer, but a significant subpopulation will not respond, likely due to the lack of antigenic mutations or the immune-evasive properties of cancer. Likewise, radiation therapy (RT) is an established cancer treatment, but local failures still occur. Clinical observations suggest that RT may expand the therapeutic reach of immunotherapy. We examine the immunobiologic and clinical rationale for combining RT and immunotherapy, two modalities yet to be used in combination in routine practice. Preclinical data indicate that RT can potentiate the systemic efficacy of immunotherapy, while activation of the innate and adaptive immune system can enhance the local efficacy of RT.

Authors

Anusha Kalbasi, Carl H. June, Naomi Haas, Neha Vapiwala

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 1,494 228
PDF 224 32
Figure 326 6
Table 68 0
Citation downloads 148 0
Totals 2,260 266
Total Views 2,526
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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