Misfolding of exportable proteins can trigger endocrinopathies. For example, misfolding of insulin can result in autosomal dominant mutant
Jordan Wright, Xiaofan Wang, Leena Haataja, Aaron P. Kellogg, Jaemin Lee, Ming Liu, Peter Arvan
Intracellular distribution of mutant proinsulins in regulated secretory cells coexpressing or not coexpressing WT proinsulin.