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Usage Information

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
Beate Lanske, … , Roland Baron, Henry M. Kronenberg
Beate Lanske, … , Roland Baron, Henry M. Kronenberg
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):399-407. https://doi.org/10.1172/JCI6629.
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Article

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development

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Abstract

Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to acceleration of differentiation of growth plate chondrocytes. To explore further the functional relationships of PTHrP and the PTH/PTHrP receptor, bones of knockout mice were analyzed early in development, and the phenotypes of double-knockout mice were characterized.

Authors

Beate Lanske, Michael Amling, Lynn Neff, Jennifer Guiducci, Roland Baron, Henry M. Kronenberg

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