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Liver sinusoidal endothelial cells and liver regeneration
Laurie D. DeLeve
Laurie D. DeLeve
Published May 1, 2013
Citation Information: J Clin Invest. 2013;123(5):1861-1866. https://doi.org/10.1172/JCI66025.
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Review Series

Liver sinusoidal endothelial cells and liver regeneration

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Abstract

Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase greatly. In contrast, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver after injury. This Review examines liver regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than mature LSECs, drive liver regeneration.

Authors

Laurie D. DeLeve

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Figure 2

Stem and progenitor cells.

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Stem and progenitor cells.
Stem cells self-renew and give rise to progen...
Stem cells self-renew and give rise to progenitor cells. Progenitor cells or transit-amplifying cells are more lineage committed than stem cells, give rise to additional progenitor cells or to specialized cells, and can only replicate a limited number of times. Two populations of liver SPCs can give rise to LSECs: BM SPCs, which are recruited to the liver after injury or partial hepatectomy, and resident or intrahepatic SPCs, which contribute to normal LSEC turnover. SPCs derive from stem cells, and the SPC population expands before giving rise to the mature LSECs.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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