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Abstract
Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase greatly. In contrast, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver after injury. This Review examines liver regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than mature LSECs, drive liver regeneration.
Authors
Laurie D. DeLeve
Figure 1
BM SPCs and liver regeneration.
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Schematic depicting the contributions of liver cells and BM SPCs to liver regeneration. Liver injury induces increased hepatic VEGF expression, which drives recruitment of HGF-rich BM SPCs and promotes expression of HGF by resident SPCs and LSECs. HGF, in turn stimulates the proliferation of hepatocytes in liver regeneration. In addition, SPCs replace LSECs that were lost during injury.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)