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Corrigendum Free access | 10.1172/JCI65314

Blood flow reprograms lymphatic vessels to blood vessels

Chiu-Yu Chen, Cara Bertozzi, Zhiying Zou, Lijun Yuan, John S. Lee, MinMin Lu, Stan J. Stachelek, Sathish Srinivasan, Lili Guo, Andres Vicente, Patricia Mericko, Robert J. Levy, Taija Makinen, Guillermo Oliver, and Mark L. Kahn

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Published July 2, 2012 - More info

Published in Volume 122, Issue 7 on July 2, 2012
J Clin Invest. 2012;122(7):2702–2702. https://doi.org/10.1172/JCI65314.
© 2012 The American Society for Clinical Investigation
Published July 2, 2012 - Version history
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Related article:

Blood flow reprograms lymphatic vessels to blood vessels
Chiu-Yu Chen, … , Guillermo Oliver, Mark L. Kahn
Chiu-Yu Chen, … , Guillermo Oliver, Mark L. Kahn
Research Article Vascular biology

Blood flow reprograms lymphatic vessels to blood vessels

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Abstract

Human vascular malformations cause disease as a result of changes in blood flow and vascular hemodynamic forces. Although the genetic mutations that underlie the formation of many human vascular malformations are known, the extent to which abnormal blood flow can subsequently influence the vascular genetic program and natural history is not. Loss of the SH2 domain–containing leukocyte protein of 76 kDa (SLP76) resulted in a vascular malformation that directed blood flow through mesenteric lymphatic vessels after birth in mice. Mesenteric vessels in the position of the congenital lymphatic in mature Slp76-null mice lacked lymphatic identity and expressed a marker of blood vessel identity. Genetic lineage tracing demonstrated that this change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than replacement by blood endothelial cells. Exposure of lymphatic vessels to blood in the absence of significant flow did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of shear stress ex vivo rapidly lost expression of PROX1, a lymphatic fate–specifying transcription factor. These findings reveal that blood flow can convert lymphatic vessels to blood vessels, demonstrating that hemodynamic forces may reprogram endothelial and vessel identity in cardiovascular diseases associated with abnormal flow.

Authors

Chiu-Yu Chen, Cara Bertozzi, Zhiying Zou, Lijun Yuan, John S. Lee, MinMin Lu, Stan J. Stachelek, Sathish Srinivasan, Lili Guo, Andres Vincente, Patricia Mericko, Robert J. Levy, Taija Makinen, Guillermo Oliver, Mark L. Kahn

×

Original citation: J. Clin. Invest. 2012;122(6):2006–2017. doi:10.1172/JCI57513.

Citation for this corrigendum: J. Clin. Invest. 2012;122(7):2702. doi:10.1172/JCI65314.

During the preparation of this manuscript, Andres Vicente’s name was spelled incorrectly in the author list. The correct author list is above.

The authors regret the error.

Version history
  • Version 1 (July 2, 2012): No description

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