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Usage Information

The role of aging upon β cell turnover
Jake A. Kushner
Jake A. Kushner
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Review Series

The role of aging upon β cell turnover

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Abstract

Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

Authors

Jake A. Kushner

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 1,986 92
PDF 235 17
Figure 330 5
Table 117 0
Citation downloads 223 0
Totals 2,891 114
Total Views 3,005
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ISSN: 0021-9738 (print), 1558-8238 (online)

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