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The sirtuin family’s role in aging and age-associated pathologies
Jessica A. Hall, … , Yoonjin Lee, Pere Puigserver
Jessica A. Hall, … , Yoonjin Lee, Pere Puigserver
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):973-979. https://doi.org/10.1172/JCI64094.
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Review Series

The sirtuin family’s role in aging and age-associated pathologies

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Abstract

The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.

Authors

Jessica A. Hall, John E. Dominy, Yoonjin Lee, Pere Puigserver

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