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Corrigendum Free access | 10.1172/JCI62813

Obesity is associated with hypothalamic injury in rodents and humans

Joshua P. Thaler, Chun-Xia Yi, Ellen A. Schur, Stephan J. Guyenet, Bang H. Hwang, Marcelo O. Dietrich, Xiaolin Zhao, David A. Sarruf, Vitaly Izgur, Kenneth R. Maravilla, Hong T. Nguyen, Jonathan D. Fischer, Miles E. Matsen, Brent E. Wisse, Gregory J. Morton, Tamas L. Horvath, Denis G. Baskin, Matthias H. Tschöp, and Michael W. Schwartz

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Published February 1, 2012 - More info

Published in Volume 122, Issue 2 on February 1, 2012
J Clin Invest. 2012;122(2):778–778. https://doi.org/10.1172/JCI62813.
© 2012 The American Society for Clinical Investigation
Published February 1, 2012 - Version history
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Related article:

Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler, … , Matthias H. Tschöp, Michael W. Schwartz
Joshua P. Thaler, … , Matthias H. Tschöp, Michael W. Schwartz
Research Article

Obesity is associated with hypothalamic injury in rodents and humans

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Abstract

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron injury were evident in the hypothalamic arcuate nucleus of rats and mice within the first week of HFD feeding. Although these responses temporarily subsided, suggesting that neuroprotective mechanisms may initially limit the damage, with continued HFD feeding, inflammation and gliosis returned permanently to the mediobasal hypothalamus. Consistent with these data in rodents, we found evidence of increased gliosis in the mediobasal hypothalamus of obese humans, as assessed by MRI. These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control.

Authors

Joshua P. Thaler, Chun-Xia Yi, Ellen A. Schur, Stephan J. Guyenet, Bang H. Hwang, Marcelo O. Dietrich, Xiaolin Zhao, David A. Sarruf, Vitaly Izgur, Kenneth R. Maravilla, Hong T. Nguyen, Jonathan D. Fischer, Miles E. Matsen, Brent E. Wisse, Gregory J. Morton, Tamas L. Horvath, Denis G. Baskin, Matthias H. Tschöp, Michael W. Schwartz

×

Original citation: J. Clin. Invest. 2012;122(1):153–162. doi:10.1172/JCI59660.

Citation for this corrigendum: J. Clin. Invest. 2012;122(2):778. doi:10.1172/JCI62813.

The present address for David Sarruf was inadvertently omitted, and the description of panel E in Figure 5 was incorrect. The correct information is below.

David A. Sarruf’s present address is: Diabetes Pharmacology, Novo Nordisk A/S, Maaloev, Denmark.

Figure 5 legend: (E) Mice fed chow for 8 months show increased astrocyte number but no overlap of processes.

The authors regret the error.

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