Plasmacytoid dendritic cells lead the charge against tumors
Sonia Jiménez-Baranda, … , Inês Pires Silva, Nina Bhardwaj
Sonia Jiménez-Baranda, … , Inês Pires Silva, Nina Bhardwaj
Published February 1, 2012; First published January 17, 2012
Citation Information: J Clin Invest. 2012;122(2):481-484. https://doi.org/10.1172/JCI61345.
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Plasmacytoid dendritic cells lead the charge against tumors

Abstract

Imiquimod is a TLR agonist that is used as an antitumor agent, mainly against skin tumors. Its clinical benefits are well described in several studies; however, the mechanisms behind its antitumor effects are not completely understood. In this issue of the JCI, Drobits and colleagues demonstrate that topical application of imiquimod suppresses cutaneous melanoma by TLR7-dependent recruitment and transformation of plasmacytoid dendritic cells into killer cells; this occurs independently of conventional adaptive immune mechanisms.

Authors

Sonia Jiménez-Baranda, Inês Pires Silva, Nina Bhardwaj

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