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Usage Information

The molecular basis of T cell acute lymphoblastic leukemia
Pieter Van Vlierberghe, Adolfo Ferrando
Pieter Van Vlierberghe, Adolfo Ferrando
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3398-3406. https://doi.org/10.1172/JCI61269.
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Review Series

The molecular basis of T cell acute lymphoblastic leukemia

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Abstract

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.

Authors

Pieter Van Vlierberghe, Adolfo Ferrando

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,926 643
PDF 159 90
Figure 231 3
Table 170 0
Citation downloads 80 0
Totals 2,566 736
Total Views 3,302
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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