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Usage Information

Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
Akiharu Kubo, Keisuke Nagao, Masayuki Amagai
Akiharu Kubo, Keisuke Nagao, Masayuki Amagai
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Review Series

Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

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Abstract

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators’ attention on epidermal barrier dysfunction as a causative mechanism. The skin’s barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.

Authors

Akiharu Kubo, Keisuke Nagao, Masayuki Amagai

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Usage data is cumulative from October 2025 through October 2026.

Usage JCI PMC
Text version 2,478 213
PDF 401 46
Figure 506 1
Table 141 0
Supplemental data 266 5
Citation downloads 274 0
Totals 4,066 265
Total Views 4,331
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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