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Usage Information

Thrombotic thrombocytopenic purpura: reducing the risk?
Michael C. Berndt, Robert K. Andrews
Michael C. Berndt, Robert K. Andrews
Published January 25, 2011
Citation Information: J Clin Invest. 2011;121(2):522-524. https://doi.org/10.1172/JCI46091.
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Commentary

Thrombotic thrombocytopenic purpura: reducing the risk?

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Abstract

von Willebrand factor (vWF) has a key role in initiating platelet aggregation, and thereby thrombus formation, that is dependent on its ability to form appropriately sized multimers. Ultralarge multimers promote the formation of the microvascular thrombi that are hallmarks of the life-threatening condition thrombotic thrombocytopenic purpura (TTP). In this issue of the JCI, Chen et al. show that the drug N-acetylcysteine (NAC) can decrease the size of vWF multimers in vitro and in vivo, resolving thrombi in mice. These data suggest that NAC could potentially be used to treat thrombotic conditions such as TTP.

Authors

Michael C. Berndt, Robert K. Andrews

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Usage data is cumulative from May 2024 through May 2025.

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PDF 60 17
Figure 96 1
Citation downloads 55 0
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Total Views 490

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