Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
Andrew S. Greenberg, Rosalind A. Coleman, Fredric B. Kraemer, James L. McManaman, Martin S. Obin, Vishwajeet Puri, Qing-Wu Yan, Hideaki Miyoshi, Douglas G. Mashek
Alterations in LD proteins in adipocytes result in increased lipolysis and promote insulin resistance.