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Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Susumu Seino, … , Tadao Shibasaki, Kohtaro Minami
Susumu Seino, … , Tadao Shibasaki, Kohtaro Minami
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(6):2118-2125. https://doi.org/10.1172/JCI45680.
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Review Series

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

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Abstract

Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.

Authors

Susumu Seino, Tadao Shibasaki, Kohtaro Minami

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