Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Susumu Seino, … , Tadao Shibasaki, Kohtaro Minami
Susumu Seino, … , Tadao Shibasaki, Kohtaro Minami
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(6):2118-2125. https://doi.org/10.1172/JCI45680.
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Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Abstract

Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.

Authors

Susumu Seino, Tadao Shibasaki, Kohtaro Minami

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Figure 1

Three modes of insulin granule dynamics.

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Three modes of insulin granule dynamics. (A) Old face. Predocked granule...
(A) Old face. Predocked granules are fused to the membrane by stimulation. (B) Restless newcomer. Granules are newly recruited and immediately fused to the plasma membrane by stimulation. (C) Resting newcomer. Granules are newly recruited, docked, and fused to the plasma membrane by stimulation. Sequential images (1 μm × 1 μm) acquired every 300 ms indicate insulin granule dynamics. Flash indicates fusion events of insulin granules. Reproduced from Proceedings of the National Academy of Sciences of the United States of America (25).