First published December 1, 2010 - More info
The mammalian target of rapamycin (mTOR) is a signaling molecule that senses environmental cues, such as nutrient status and oxygen supply, to regulate cell growth, proliferation, and other functions. Unchecked, sustained mTOR activity results in defects in HSC function. Inflammatory conditions, such as autoimmune disease, are often associated with defective hematopoiesis. Here, we investigated whether hyperactivation of mTOR in HSCs contributes to hematopoietic defects in autoimmunity and inflammation. We found that in mice deficient in
Chong Chen, Yu Liu, Yang Liu, Pan Zheng
Original citation: J Clin Invest.2010;120(11):4091–4101. doi:10.1172/JCI43873.
Citation for this corrigendum: J Clin Invest. 2010;120(12):4583. doi:10.1172/JCI43873C1.
The measurement of cytokine IL-12p70 was incorrectly identified in the section of Results titled “Multiple inflammatory cytokines are responsible for LPS-induced HSC defects” and in Figure 4A. The correct sentence and figure appear below.
The authors regret the error.