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CorrigendumMetabolism Free access | 10.1172/JCI39901C1

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

Marie-Therese Rached, Aruna Kode, Barbara C. Silva, Dae Young Jung, Susan Gray, Helena Ong, Ji-Hye Paik, Ronald A. DePinho, Jason K. Kim, Gerard Karsenty, and Stavroula Kousteni

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Published March 1, 2010 - More info

Published in Volume 120, Issue 3 on March 1, 2010
J Clin Invest. 2010;120(3):932–932. https://doi.org/10.1172/JCI39901C1.
© 2010 The American Society for Clinical Investigation
Published March 1, 2010 - Version history
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Related article:

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
Marie-Therese Rached, … , Gerard Karsenty, Stavroula Kousteni
Marie-Therese Rached, … , Gerard Karsenty, Stavroula Kousteni
Research Article

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

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Abstract

Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. It is unknown, however, how this osteoblast function is regulated transcriptionally. As FoxO1 is a forkhead family transcription factor known to regulate several key aspects of glucose homeostasis, we investigated whether its expression in osteoblasts may contribute to its metabolic functions. Here we show that mice lacking Foxo1 only in osteoblasts had increased pancreatic β cell proliferation, insulin secretion, and insulin sensitivity. The ability of osteoblast-specific FoxO1 deficiency to affect metabolic homeostasis was due to increased osteocalcin expression and decreased expression of Esp, a gene that encodes a protein responsible for decreasing the bioactivity of osteocalcin. These results indicate that FoxO1 expression in osteoblasts contributes to FoxO1 control of glucose homeostasis and identify FoxO1 as a key modulator of the ability of the skeleton to function as an endocrine organ regulating glucose metabolism.

Authors

Marie-Therese Rached, Aruna Kode, Barbara C. Silva, Dae Young Jung, Susan Gray, Helena Ong, Ji-Hye Paik, Ronald A. DePinho, Jason K. Kim, Gerard Karsenty, Stavroula Kousteni

×

Original citation: J. Clin. Invest.2010;120(1):357–368. doi:10.1172/JCI39901.

Citation for this corrigendum: J. Clin. Invest.2010;120(3):932. doi:10.1172/JCI39901C1.

The legend for Figure 5H was incorrect. The correct text appears below.

(H) Changes in uncarboxylated or undercarboxylated Ocn in serum of WT and Foxo1ob–/– mice; n = 5 mice/group.

The authors regret the errors.

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