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Usage Information

Dendritic cells in intestinal homeostasis and disease
Maria Rescigno, Antonio Di Sabatino
Maria Rescigno, Antonio Di Sabatino
Published September 1, 2009
Citation Information: J Clin Invest. 2009;119(9):2441-2450. https://doi.org/10.1172/JCI39134.
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Science in Medicine

Dendritic cells in intestinal homeostasis and disease

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Abstract

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.

Authors

Maria Rescigno, Antonio Di Sabatino

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,560 181
PDF 110 36
Figure 222 2
Table 79 0
Citation downloads 101 0
Totals 2,072 219
Total Views 2,291
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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