First published May 3, 2010 - More info
The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias. The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.
Raghu Kalluri, Robert A. Weinberg
Original citation: J Clin Invest. 2009;119(6):1420–1428. doi:10.1172/JCI39104.
Citation for this corrigendum: J Clin Invest. 2010;120(5):1786. doi:10.1172/JCI39104C1.
In the section titled “Type 3 EMT: EMT associated with cancer progression and metastasis,” the phenotype of the cells purified from normal and malignant breast cancer tissue was given incorrectly. The correct sentence appears below.
Interestingly, CD44hiCD24lo cells purified from normal and malignant breast cancer tissue exhibit features of an EMT, and human cancer cells induced to undergo EMT exhibit stem cell–like properties and increased metastatic potential (84).
The authors regret the error.