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The basics of epithelial-mesenchymal transition
Raghu Kalluri, Robert A. Weinberg
Raghu Kalluri, Robert A. Weinberg
Published June 1, 2009
Citation Information: J Clin Invest. 2009;119(6):1420-1428. https://doi.org/10.1172/JCI39104.
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Review Series

The basics of epithelial-mesenchymal transition

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Abstract

The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias. The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.

Authors

Raghu Kalluri, Robert A. Weinberg

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Figure 2

Different types of EMT.

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Different types of EMT.
(A) Type 1 EMT is associated with implantation a...
(A) Type 1 EMT is associated with implantation and embryonic gastrulation and gives rise to the mesoderm and endoderm and to mobile neural crest cells. The primitive epithelium, specifically the epiblast, gives rise to primary mesenchyme via an EMT. This primary mesenchyme can be re-induced to form secondary epithelia by a MET. It is speculated that such secondary epithelia may further differentiate to form other types of epithelial tissues and undergo subsequent EMT to generate the cells of connective tissue, including astrocytes, adipocytes, chondrocytes, osteoblasts, and muscle cells. (B) EMTs are re-engaged in the context of inflammation and fibrosis and represent the type 2 EMTs. Unlike the type 1 EMT, the type 2 EMT is expressed over extended periods of time and can eventually destroy an affected organ if the primary inflammatory insult is not removed or attenuated. (C) Finally, the secondary epithelia associated with many organs can transform into cancer cells that later undergo the EMTs that enable invasion and metastasis, thereby representing type 3 EMTs.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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