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A decade of molecular pathogenomic analysis of group A Streptococcus
James M. Musser, Samuel A. Shelburne III
James M. Musser, Samuel A. Shelburne III
Published September 1, 2009
Citation Information: J Clin Invest. 2009;119(9):2455-2463. https://doi.org/10.1172/JCI38095.
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A decade of molecular pathogenomic analysis of group A Streptococcus

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Abstract

Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated a systems biology investigative strategy designed to enhance and accelerate our understanding of disease processes. Here, we provide examples of the progress made by exploiting an integrated genome-wide research platform to gain new insight into molecular pathogenesis. The studies have provided many new avenues for basic and translational research.

Authors

James M. Musser, Samuel A. Shelburne III

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Figure 1

Schematic depicting how genome-wide analyses have revealed previously unsuspected links between carbohydrate metabolism and virulence.

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Schematic depicting how genome-wide analyses have revealed previously un...
Examples of recently discovered relationships between carbohydrate catabolism and virulence include (i) the role of LacD.1 in controlling SpeB production, (ii) identification of the SptR/S saliva persistence pathway, (iii) the discovery of regulation of virulence factors by CcpA, and (iv) the differential role in virulence factor regulation (bottom) and catabolism (top) of the 2 lactose operons. Panel i is reprinted with permission from EMBO Journal (79). Panels ii and iii are adapted from Proceedings of the National Academy of Sciences U. S. A. (ref. 75 and ref. 77, respectively).

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ISSN: 0021-9738 (print), 1558-8238 (online)

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