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Usage Information

Megakaryocyte biology and related disorders
Liyan Pang, Mitchell J. Weiss, Mortimer Poncz
Liyan Pang, Mitchell J. Weiss, Mortimer Poncz
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Megakaryocyte biology and related disorders

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Abstract

Platelets, derived from megakaryocytes, have an essential role in thrombosis and hemostasis. Over the past 10 years, a great deal of new information has been obtained concerning the various aspects of hematopoiesis necessary to maintain a steady-state platelet level to support physiologic hemostasis. Here we discuss the differentiation of HSCs into megakaryocytes, with emphasis on the key cytokine signaling pathways and hematopoietic transcription factors. Recent insight into these processes elucidates the molecular bases of numerous acquired and inherited hematologic disorders. It is anticipated that the growing knowledge in these areas may be exploited for new therapeutic strategies to modulate both platelet numbers and their thrombogenicity.

Authors

Liyan Pang, Mitchell J. Weiss, Mortimer Poncz

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 1,951 308
PDF 214 29
Figure 420 0
Citation downloads 174 0
Totals 2,759 337
Total Views 3,096
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ISSN: 0021-9738 (print), 1558-8238 (online)

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