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Usage Information

Pharmacological manipulation of Bcl-2 family members to control cell death
Anthony Letai
Anthony Letai
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Review Series

Pharmacological manipulation of Bcl-2 family members to control cell death

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Abstract

The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.

Authors

Anthony Letai

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 1,169 52
PDF 216 9
Figure 300 1
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Total Views 1,879
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ISSN: 0021-9738 (print), 1558-8238 (online)

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