Usage Information

The latency-associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma
Farnaz D. Fakhari, … , Yogita Kanan, Dirk P. Dittmer
Farnaz D. Fakhari, … , Yogita Kanan, Dirk P. Dittmer
Published March 1, 2006
Citation Information: J Clin Invest. 2006;116(3):735-742. https://doi.org/10.1172/JCI26190.
View: Text | PDF
Research Article Immunology

The latency-associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma

Abstract

Kaposi sarcoma–associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANA’s contribution to lymphomagenesis in vivo we generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM+IgD+ B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.

Authors

Farnaz D. Fakhari, Joseph H. Jeong, Yogita Kanan, Dirk P. Dittmer

×

Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 432 35
PDF 68 14
Figure 364 4
Table 51 0
Supplemental data 39 0
Citation downloads 73 0
Totals 1,027 53
Total Views 1,080
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement